As we have embarked on our expanded mission into immuno-oncology development and commercialization, our immuno-oncology scientific advisory board (SAB) provides strategic guidance and direction for our immuno-oncology R&D programs. The SAB includes scientific and clinical advisors who have made significant contributions to advancing the field of immuno-oncology.
Professor, Molecular and Medical Pharmacology, Director, UCLA Metabolomics Center
Dr. Graeber takes an interdisciplinary ‘systems biology’ approach that merges biology, chemistry, mathematics and computation/bioinformatics to understand how cancer cells communicate with their environments, process nutrients and evade therapies. Dr. Graeber gathers multiple types of large data sets from patient tumor samples and then applies computational approaches to find trends, such as how tumor cells metabolize nutrients differently from other cells. The ultimate goal of this work is to identify new ways to diagnose and treat cancer on a cellular, patient-specific level.
Dr. Graeber aims to make advances in understudied cancers with few or no available targeted therapies. Rather than focusing on how cancer affects one specific organ, such as the prostate or lungs, he looks for commonalities among different cancer types in order to identify vulnerabilities that can be targeted by new drugs or cellular therapies. He is currently collaborating with clinician scientists to identify the common genetic activities that enable aggressive, treatment-resistant cancers from different tissues to metastasize.
Another area of focus in Dr. Graeber’s lab is determining how cancer cells de-differentiate, or revert to an earlier stage of development. De-differentiation can also be linked to cancer stem cells, which are able to self-renew and give rise to all cell types found in a tumor. De-differentiated cells can evade common treatments such as chemotherapy and radiation and cause recurrence of the disease. He discovered that melanomas – cancers that arise from the cells that produce pigments – can be divided into four distinct subtypes according to their stages of differentiation or maturity. He then found that less-mature melanoma cells showed sensitivity to a self-inflicted cell death called ferroptosis. This led to the finding that certain subtypes of melanoma could be targeted by a combination of existing cancer therapies and ferroptosis-inducing drugs.
Previously Senior Executive at Amgen and Merck
Dr. Gresser received his Ph.D. in Biochemistry in 1976 from Brandeis University, where his thesis research was done under the supervision of W.P. Jencks on the mechanism of ester aminolysis. He did postdoctoral studies at the Molecular Biology Institute at UCLA on the mitochondrial and chloroplast proton translocating ATP synthases, under the supervision of Paul D. Boyer.
In 1980, Dr. Gresser joined the Department of Chemistry at Simon Fraser University in Burnaby, British Columbia where he eventually became Professor of Chemistry. While there, Mike received the Excellence in Teaching Award, and did research on the biochemistry of Vanadium V, and on the mitochondrial proton-translocating ATPase.
In 1988, Dr. Gresser joined the Merck Frosst Center for Therapeutic Research in Kirkland, Quebec as Director of Biochemistry, and later became Executive Director of Biochemistry and Molecular Biology. Mike’s team worked on a variety of small molecule drug discovery programs, resulting in the introduction of numerous molecules into clinical trials. Three of these molecules, Singulair, Vioxx, and Arcoxia became products.
From 2000 to 2006 he was VP Research and Head of Inflammation Research at Amgen. His teams at Amgen worked on many molecular targets, introducing numerous small molecules, human antibodies, and other proteins into development.
Dr. Gresser has been advisor/SAB/Board member of several biotech companies, including Trillium, Oxford Biotherapeutics, and Zymeworks. From 2009 to 2014 he served as Chief Scientific Officer for the Myelin Repair Foundation, and from 2014 through 2018 served as Chief Scientific Officer for ImmunGene. Dr. Gresser has a faculty appointment as Adjunct Assistant Professor in the Department of Chemistry and Biochemistry at the University of California, Los Angeles, and in 2019 co-founded Aksivi Therapeutics, where he serves as Chief Scientific Officer.
Biomedical Scholar Professor, Georgetown University
Dr. Khleif, M.D. is an immunologist and immune therapist. His research program is ”translational tumor immunology” focused on understanding mechanisms through which the immune system and cancer cells interact and how to overcome tumor tolerance in developing therapeutic approaches. Specifically, his research interests include developing novel immune therapeutics, cancer vaccines and delineating the mechanisms of resistance to immunotherapy.
Prior to transferring his research program to Georgetown University in 2017, Dr. Khleif served as the Director of Georgia Cancer Center, Augusta University. As Director of the Georgia Cancer Center, Dr. Khleif oversaw the development of a large integrated program of basic scientists and clinicians merging the Cancer Center strength in immunology, inflammation and tolerance basic science and immune therapy. Dr. Khleif was an intramural NIH scientist for about 20 years. While at NCI, he also served as a leader of the Cancer Vaccine Section, leading a nationally active Immune Therapy Program. His laboratory has conducted some of the earliest clinical trials in antigen vaccines and was the first to conduct vaccines against mutant oncogenes. In addition, in the past few years some of the discoveries made in his laboratory has been translated into first- in-human immune therapy clinical trials.
Dr. Khleif has published several studies on the mechanisms of tumor-induced suppression in animal models and have overcome such inhibition by developing strategies that have been translated into clinical trials. His laboratory has developed models to understand how different kinds of immune therapies can be combined to work synergistically and translated into clinical trials.
Professor of Medicine (Hematology), Chair - Division of Hematology, Stanford University School of Medicine
Dr. Majeti is Professor of Medicine, Chief of the Division of Hematology, and Member of the Institute for Stem Cell Biology and Regenerative Medicine at the Stanford University School of Medicine. He was an undergraduate at Harvard, earned his M.D. and Ph.D. from UCSF, and trained in Internal Medicine at Brigham and Women’s Hospital in Boston. Dr. Majeti completed his Hematology Fellowship at Stanford, and is a board-certified hematologist. While at Stanford, he completed post-doctoral training in the laboratory of Irving Weissman, where he investigated acute myeloid leukemia (AML) stem cells and therapeutic targeting with anti-CD47 antibodies. With Dr. Weissman, he developed a humanized anti-CD47 antibody, initiated first-in- human clinical trials. Dr. Majeti directs an active NIH-funded laboratory that focuses on the molecular characterization and therapeutic targeting of leukemia stem cells in human hematologic disorders, particularly AML, and has published more than 90 peer-reviewed articles.
Dr. Majeti is a recipient of the Burroughs Welcome Career Award for Medical Scientists, the New York Stem Cell Foundation Robertson Investigator Award, and the Leukemia and Lymphoma Society Scholar Award. Dr. Majeti is currently a member of the Committee on Scientific Affairs for the American Society of Hematology (ASH) and serves of the editorial board of Blood and eLife.
Director, Sanford-Burnham Medical Research Institute
Dr. Ware is a Director and Professor at the Infectious and Inflammatory Disease Center at the Sanford Burnham Prebys Medical Discovery Institute in La Jolla California. He is a leading immunologist and virologist, internationally recognized for his scientific discoveries and advances in the study of the immune system, leading to new therapeutics for autoimmune and viral diseases and cancer.
Dr. Ware received his doctorate in 1979 in Molecular Biology and Biochemistry at the University of California, Irvine, where he began his scientific research career by studying tumor destroying cytokines with Professor Gale A. Granger. Dr. Ware’s postdoctoral training included research with Dr. Jack Strominger and Dr. Tim Springer at the Dana-Farber Cancer Institute, Harvard Medical School. Dr. Ware established his own research laboratory in 1982 in the Biomedical Sciences Program at the University of California, Riverside, advancing to full professor in 1993. In 1996, he joined the La Jolla Institute for Allergy and Immunology as head of the Division of Molecular Immunology.
In 2010, he was recruited to the Sanford Burnham Prebys Medical Discovery Institute as Center Director, and also holds a joint appointment in the Department of Biology at the University of California, San Diego.